Baculoviruses are arthropod-specific viruses containing large double-stranded circular DNA genomes of 80,000–180,000 bp. In recent years, they have been utilized for producing complex eukaryotic proteins in insect cell cultures. There are several benefits of using baculovirus to express target protein, such as the virus being able to package large inserts, ability of post-translational modifications, enhanced protein folding and function, high expression levels and safety.